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Pharmacokinetics and pharmacodynamics of Ro 44–3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers

AIMS: This study constituted the first administration of the oral platelet inhibitor, sibrafiban, to humans. The aim was to investigate the pharmacokinetics and pharmacodynamics of Ro 44–3888, the active principle of sibrafiban, after single ascending oral doses of sibrafiban. Particular emphasis wa...

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Autores principales: Wittke, Bärbel, Mackie, Ian J, Machin, Samuel J, Timm, Uwe, Zell, Manfred, Goggin, Timothy
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014180/
https://ncbi.nlm.nih.gov/pubmed/10336576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00931.x
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