Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of μ- and δ-opioid receptor antagonists

BACKGROUND AND PURPOSE: Ultralow doses of naltrexone, a non-selective opioid antagonist, have previously been found to augment acute morphine analgesia and block the development of tolerance to this effect. Since morphine tolerance is dependent on the activity of μ and δ receptors, the present study...

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Bibliographic Details
Main Authors: Abul-Husn, N S, Sutak, M, Milne, B, Jhamandas, K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014123/
https://ncbi.nlm.nih.gov/pubmed/17502848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707277
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