Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain

BACKGROUND AND PURPOSE: Most of the pharmaceuticals target G-protein-coupled receptors (GPCRs) which can generally activate different signalling events. The aim of this study was to achieve functional selectivity of corticotropin-releasing factor receptor type 1 (CRF(1)) ligands. EXPERIMENTAL APPROA...

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Detalhes bibliográficos
Main Authors: Beyermann, M, Heinrich, N, Fechner, K, Furkert, J, Zhang, W, Kraetke, O, Bienert, M, Berger, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014118/
https://ncbi.nlm.nih.gov/pubmed/17533422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707293
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