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Discovery of P2X(7) receptor-selective antagonists offers new insights into P2X(7) receptor function and indicates a role in chronic pain states
ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including peripheral macrophages and glial cells in the CNS. Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflammatory cytokine interleukin-1β and followi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013998/ https://ncbi.nlm.nih.gov/pubmed/17471177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707265 |
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