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Discovery of P2X(7) receptor-selective antagonists offers new insights into P2X(7) receptor function and indicates a role in chronic pain states

ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including peripheral macrophages and glial cells in the CNS. Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflammatory cytokine interleukin-1β and followi...

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Bibliografski detalji
Glavni autori: Donnelly-Roberts, D L, Jarvis, M F
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013998/
https://ncbi.nlm.nih.gov/pubmed/17471177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707265
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