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Antagonist, partial agonist and antiproliferative actions of B-9870 (CU201) as a function of the expression and density of the bradykinin B(1) and B(2) receptors
BACKGROUND AND PURPOSE: A bradykinin (BK) B(2) receptor (B(2)R) antagonist, B-9870 (CU201), has been proposed to behave as a ‘biased agonist' at B(2)Rs and to exert anti-neoplasic effects. It was unclear whether these effects were determined by the activation of B(2)Rs by the drug. B-9870 was e...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2006
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013894/ https://ncbi.nlm.nih.gov/pubmed/17179948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706982 |
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