New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis

BACKGROUND AND PURPOSE: The cytochrome P450 2B6 (CYP2B6) enzyme metabolises a number of clinically important drugs. Drug-drug interactions resulting from inhibition or induction of CYP2B6 activity may cause serious adverse effects. The aims of this study were to construct a three-dimensional structu...

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Bibliografiske detaljer
Main Authors: Korhonen, L E, Turpeinen, M, Rahnasto, M, Wittekindt, C, Poso, A, Pelkonen, O, Raunio, H, Juvonen, R O
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013880/
https://ncbi.nlm.nih.gov/pubmed/17325652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707173
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