A comparison of the pharmacological properties of guinea-pig and human recombinant 5-HT(4) receptors

BACKGROUND AND PURPOSE: 5-HT(4) receptor agonists are used therapeutically to treat disorders of reduced gastrointestinal motility. Since such compounds are evaluated in guinea-pigs, we cloned, expressed and pharmacologically characterized the guinea-pig 5-HT(4) and human 5-HT(4(b)) splice variant,...

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Detalhes bibliográficos
Main Authors: Vickery, R G, Mai, N, Kaufman, E, Beattie, D T, Pulido-Rios, T, O'Keefe, M, Humphrey, P P A, Smith, J A M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013860/
https://ncbi.nlm.nih.gov/pubmed/17293885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707154
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