Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity

BACKGROUND AND PURPOSE: Ivabradine, a specific and use-dependent I (f) inhibitor, exerts anti-ischaemic activity purely by reducing heart rate. The aim of this work was to characterize its effect on the predominant HCN channel isoform expressed in human sino-atrial nodes (hSAN), to determine its kin...

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Detalhes bibliográficos
Main Authors: Thollon, C, Bedut, S, Villeneuve, N, Cogé, F, Piffard, L, Guillaumin, J-P, Brunel-Jacquemin, C, Chomarat, P, Boutin, J-A, Peglion, J-L, Vilaine, J-P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013855/
https://ncbi.nlm.nih.gov/pubmed/17128289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706940
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