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Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells

BACKGROUND AND PURPOSE: Apoptosis is a fundamental process required for neuronal development but also occurs in most of the common neurodegenerative disorders. In an attempt to obtain an anti-apoptotic neuroprotective compound from natural products, we isolated the diterpenoids, pinusolide and 15-MP...

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Detalhes bibliográficos
Main Authors: Koo, K A, Lee, M K, Kim, S H, Jeong, E J, Kim, S Y, Oh, T H, Kim, Y C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013848/
https://ncbi.nlm.nih.gov/pubmed/17143305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706944
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