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Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

Recombinant adenoviruses (Ads) are highly efficient at transferring foreign genes to the liver in vivo; however, the duration of gene expression is limited by the host antiviral immune response, which prevents expression upon readministration of the virus. To test whether overexpression of the immun...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ilan, Yaron, Droguett, Gustavo, Chowdhury, Namita Roy, Li, Yongan, Sengupta, Krishna, Thummala, Narsing R., Davidson, Anne, Chowdhury, Jayanta Roy, Horwitz, Marshall S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20132/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122239/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2587
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