THE ABSENCE OF ENDOGENOUS β-ENDORPHIN SELECTIVELY BLOCKS PHOSPHORYLATION AND DESENSITIZATION OF MU OPIOID RECEPTORS FOLLOWING PARTIAL SCIATIC NERVE LIGATION

Phosphorylation of specific sites in the 2(nd) intracellular loop and in the C-terminal domain have previously been suggested to cause desensitization and internalization of the mu-opioid receptor (MOP-R). To assess sites of MOP-R phosphorylation in vivo, affinity-purified, phosphoselective antibodi...

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Main Authors: Petraschka, Michael, Li, Shuang, Gilbert, Terri L., Westenbroek, Ruth E., Bruchas, Michael R., Schreiber, Selena, Lowe, Janet, Low, Malcolm J., Pintar, John E., Chavkin, Charles
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2012364/
https://ncbi.nlm.nih.gov/pubmed/17467916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.03.029
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