Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib-Mediated Amikacin Resistance by Antisense Oligodeoxynucleotides

Amikacin has been very useful in the treatment of infections caused by multiresistant bacteria because it is refractory to the actions of most modifying enzymes. However, the spread of AAC(6′)-I-type acetyltransferases, enzymes capable of catalyzing inactivation of amikacin, has rendered this antibi...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Sarno, Renee, Ha, Hongphuc, Weinsetel, Natalia, Tolmasky, Marcelo E.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2003
Subjects:	Mechanisms of Resistance
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC201158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14506044/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.10.3296-3304.2003
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