Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection

Nonhuman primates were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infection. Cynomolgus macaques were infected with low doses of virulent M. tuberculosis via bronchoscopic instillation into the lung. All monkeys were successfully infected, based on tuberculi...

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Autors principals: Capuano, Saverio V., Croix, Denise A., Pawar, Santosh, Zinovik, Angelica, Myers, Amy, Lin, Philana L., Bissel, Stephanie, Fuhrman, Carl, Klein, Edwin, Flynn, JoAnne L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Bacterial Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC201048/
https://ncbi.nlm.nih.gov/pubmed/14500505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.10.5831-5844.2003
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