Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection

Nonhuman primates were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infection. Cynomolgus macaques were infected with low doses of virulent M. tuberculosis via bronchoscopic instillation into the lung. All monkeys were successfully infected, based on tuberculi...

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Bibliographische Detailangaben
Hauptverfasser: Capuano, Saverio V., Croix, Denise A., Pawar, Santosh, Zinovik, Angelica, Myers, Amy, Lin, Philana L., Bissel, Stephanie, Fuhrman, Carl, Klein, Edwin, Flynn, JoAnne L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Bacterial Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC201048/
https://ncbi.nlm.nih.gov/pubmed/14500505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.10.5831-5844.2003
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