CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques

CD4 T cells are believed to be important in protection against Mycobacterium tuberculosis, but the relative contribution to control of initial or latent infection is not known. Antibody-mediated depletion of CD4 T cells in M. tuberculosis-infected cynomolgus macaques was used to study the role of CD...

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Detalles Bibliográficos
Autores principales: Lin, Philana Ling, Rutledge, Tara, Green, Angela M., Bigbee, Matthew, Fuhrman, Carl, Klein, Edwin, Flynn, JoAnne L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
Materias:
Animal Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505050/
https://ncbi.nlm.nih.gov/pubmed/22480184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2012.0028
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