Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane

Exocytosis at the apical surface of pancreatic acinar cells occurs in the presence of physiological concentrations of cholecystokinin (CCK) but is inhibited at high concentrations. Here we show that Munc18c is localized predominantly to the basal membranes of acinar cells. Supramaximal but not subma...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Gaisano, Herbert Y., Lutz, Manfred P., Leser, Juergen, Sheu, Laura, Lynch, Grit, Tang, Lan, Tamori, Yoshikazu, Trimble, William S., Salapatek, Anne Marie F.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11733555/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9110
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