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Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane

Exocytosis at the apical surface of pancreatic acinar cells occurs in the presence of physiological concentrations of cholecystokinin (CCK) but is inhibited at high concentrations. Here we show that Munc18c is localized predominantly to the basal membranes of acinar cells. Supramaximal but not subma...

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Vydáno v:J Clin Invest
Hlavní autoři: Gaisano, Herbert Y., Lutz, Manfred P., Leser, Juergen, Sheu, Laura, Lynch, Grit, Tang, Lan, Tamori, Yoshikazu, Trimble, William S., Salapatek, Anne Marie F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2001
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200979/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11733555/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9110
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