Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms.

In rat pancreatic acinar tissue adenylate cyclase is stimulated by low concentrations of secretin, while higher concentrations also activate phosphatidylinositol bisphosphate hydrolysis. By the use of the secretin analogues [Tyr10,13]secretin and [Tyr10,13,Phe22,Trp25]secretin, we have shown that su...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Trimble, E R, Bruzzone, R, Biden, T J, Meehan, C J, Andreu, D, Merrifield, R B
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1987
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304825/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2437575/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.10.3146
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