Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

To determine whether a functional type II receptor of transforming growth factor β (TGF-β) is required to mediate the growth inhibitory effect of TGF-β on the skin in vivo, we have generated transgenic mice that overexpress a dominant negative-type II TGF-β receptor (ΔβRII) in the epidermis. The ΔβR...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, Xiao-Jing, Greenhalgh, David A., Bickenbach, Jackie R., Jiang, Aibo, Bundman, Donnie S., Krieg, Thomas, Derynck, Rik, Roop, Dennis R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20097/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122204/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2386
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