Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

RANK, the receptor activator of NF-κB, and its ligand RANKL (initially termed TRANCE, also termed ODF and OPGL), are a TNF superfamily receptor-ligand pair that govern the development and function of osteoclasts, lymphoid tissue, and mammary epithelium. While TNF family cytokines share a common stru...

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Pubblicato in:	J Clin Invest
Autori principali:	Lam, Jonathan, Nelson, Christopher A., Ross, F. Patrick, Teitelbaum, Steven L., Fremont, Daved H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200957/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13890
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