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The molecular mechanism of osteoclastogenesis in rheumatoid arthritis

Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte–macrophage lineage under the control of bone-forming osteoblasts. We have cloned an osteoblast-derived factor essential for osteoclastogenesis, the receptor activator of NF-κB ligand (RANKL). Synovial fibroblasts and activa...

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Detalhes bibliográficos
Main Authors: Udagawa, Nobuyuki, Kotake, Shigeru, Kamatani, Naoyuki, Takahashi, Naoyuki, Suda, Tatsuo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128939/
https://ncbi.nlm.nih.gov/pubmed/12223101
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