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Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

RANK, the receptor activator of NF-κB, and its ligand RANKL (initially termed TRANCE, also termed ODF and OPGL), are a TNF superfamily receptor-ligand pair that govern the development and function of osteoclasts, lymphoid tissue, and mammary epithelium. While TNF family cytokines share a common stru...

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Autori principali: Lam, Jonathan, Nelson, Christopher A., Ross, F. Patrick, Teitelbaum, Steven L., Fremont, Daved H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC200957/
https://ncbi.nlm.nih.gov/pubmed/11581298
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