Observations on catalysis by hammerhead ribozymes are consistent with a two-divalent-metal-ion mechanism

Significant cleavage by hammerhead ribozymes requires activation by divalent metal ions. Several models have been proposed to account for the influence of metal ions on hammerhead activity. A number of recent papers have presented data that have been interpreted as supporting a one-metal-hydroxide-i...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Pontius, Brian W., Lott, William B., von Hippel, Peter H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1997
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20080/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122187/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2290
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