Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases

The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate and desensitize agonist-occupied GPCRs. GRK2-mediated receptor phosphorylation is preceded by the agonist-dependent membrane association of this enzyme. Previous in vitro studies with purified proteins have suggested that this transl...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Daaka, Yehia, Pitcher, Julie A., Richardson, Mark, Stoffel, Robert H., Robishaw, Janet D., Lefkowitz, Robert J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20061/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122168/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2180
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