Targeting RNA decay with 2′,5′ oligoadenylate-antisense in respiratory syncytial virus-infected cells

Treatment of human cells with 2′,5′ oligoadenylate covalently linked to antisense (2–5A-antisense) results in the selective cleavage of targeted RNA species by 2–5A-dependent RNase L. Here we show that 2–5A-antisense containing stabilizing modifications at both termini are effective in suppressing t...

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Hlavní autoři: Cirino, Nick M., Li, Guiying, Xiao, Wei, Torrence, Paul F., Silverman, Robert H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences of the USA 1997
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC20021/
https://ncbi.nlm.nih.gov/pubmed/9050883
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