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Targeting RNA decay with 2′,5′ oligoadenylate-antisense in respiratory syncytial virus-infected cells
Treatment of human cells with 2′,5′ oligoadenylate covalently linked to antisense (2–5A-antisense) results in the selective cleavage of targeted RNA species by 2–5A-dependent RNase L. Here we show that 2–5A-antisense containing stabilizing modifications at both termini are effective in suppressing t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC20021/ https://ncbi.nlm.nih.gov/pubmed/9050883 |
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