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Severe inflammatory arthritis and lymphadenopathy in the absence of TNF

It has been postulated that TNF has a pivotal role in a cytokine cascade that results in joint inflammation and destruction in rheumatoid arthritis (RA). To evaluate this, we examined the response of TNF-deficient (Tnf(–/–)) mice in two models of RA. Collagen-induced arthritis (CIA) was induced by i...

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Autors principals: Campbell, Ian K., O’Donnell, Kristy, Lawlor, Kate E., Wicks, Ian P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC200197/
https://ncbi.nlm.nih.gov/pubmed/11413159
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