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Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation

Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of cytokine signaling. To investigate the role of SOCS-1 in regulating inflammatory and immune responses in disease, acute inflammatory arthritis was induced in mice lacking SOCS-1. Expression of SOCS-1 protein was detected within s...

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Bibliographic Details
Main Authors: Egan, Paul J., Lawlor, Kate E., Alexander, Warren S., Wicks, Ian P.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC153765/
https://ncbi.nlm.nih.gov/pubmed/12639998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316156
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