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Loss of Myostatin (GDF8) Function Increases Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but the Osteogenic Effect is Ablated with Unloading
Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further define the role of myostatin in regulating bone mass we sought to determine if loss of myostatin func...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2001954/ https://ncbi.nlm.nih.gov/pubmed/17383950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2007.02.012 |
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