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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation

Kaposi’s sarcoma–associated (KS-associated) herpesvirus (KSHV) is a B-lymphotropic agent linked to AIDS-related lymphoproliferative disorders and KS. We and others have earlier identified two viral genes, K3 and K5, that encode endoplasmic reticulum proteins that downregulate surface MHC-I chains by...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Coscoy, Laurent, Ganem, Don
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC200195/
https://ncbi.nlm.nih.gov/pubmed/11413168
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