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Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis

Down-regulation of the cell surface display of class I MHC proteins is an important mechanism of immune evasion by human and animal viruses. Herpesviruses in particular encode a variety of proteins that function to lower MHC I display by several mechanisms. These include binding and retention of MHC...

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Autores principales: Coscoy, Laurent, Ganem, Don
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC16668/
https://ncbi.nlm.nih.gov/pubmed/10859362
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