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Monitoring Aminoglycoside-Induced Conformational Changes in 16S rRNA through Acrylamide Quenching

Fluorescence of 2-aminopurine (2AP) substituted A site and acrylamide quenching were used to study the interactions of paromomycin and neamine with the decoding region of 16S rRNA. The results reveal that paromomycin binding to the A-site RNA leads to increased exposure of residue A1492. In contrast...

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Bibliografiska uppgifter
Huvudupphovsmän: Chao, Pei-Wen, Chow, Christine S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2001229/
https://ncbi.nlm.nih.gov/pubmed/17399988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.03.025
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