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Monitoring Aminoglycoside-Induced Conformational Changes in 16S rRNA through Acrylamide Quenching
Fluorescence of 2-aminopurine (2AP) substituted A site and acrylamide quenching were used to study the interactions of paromomycin and neamine with the decoding region of 16S rRNA. The results reveal that paromomycin binding to the A-site RNA leads to increased exposure of residue A1492. In contrast...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2001229/ https://ncbi.nlm.nih.gov/pubmed/17399988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.03.025 |
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