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SPECIFIC BLOCKAGE OF LIGAND-INDUCED DEGRADATION OF THE AH RECEPTOR BY PROTEASOME BUT NOT CALPAIN INHIBITORS IN CELL CULTURE LINES FROM DIFFERENT SPECIES
To firmly establish the pathway involved in ligand-induced degradation of the AHR, cell lines derived from mouse rat or human tissues were exposed to inhibitors specific to the proteasome or calpain proteases and exposed to TCDD. The level of endogenous AHR and CYP1A1 protein was then evaluated by q...
Tallennettuna:
| Päätekijä: | |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2001188/ https://ncbi.nlm.nih.gov/pubmed/17445780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.03.021 |
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