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A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

The proapoptotic PB1-F2 protein of influenza A viruses has been shown to contribute to pathogenesis in the mouse model. Expression of full-length PB1-F2 increases the pathogenesis of the influenza A virus, causing weight loss, slower viral clearance, and increased viral titers in the lungs. After co...

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Библиографические подробности
Главные авторы: Conenello, Gina M, Zamarin, Dmitriy, Perrone, Lucy A, Tumpey, Terrence, Palese, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000966/
https://ncbi.nlm.nih.gov/pubmed/17922571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030141
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