Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

Functional telomeres are required for the replicability of cancer cells. The G-rich strand of telomeric DNA can fold into a 4-stranded structure known as the G-quadruplex (G4), whose stabilization alters telomere function limiting cancer cell growth. Therefore, the G4 ligand RHPS4 may possess antitu...

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Detalhes bibliográficos
Main Authors: Salvati, Erica, Leonetti, Carlo, Rizzo, Angela, Scarsella, Marco, Mottolese, Marcella, Galati, Rossella, Sperduti, Isabella, Stevens, Malcolm F.G., D’Incalci, Maurizio, Blasco, Maria, Chiorino, Giovanna, Bauwens, Serge, Horard, Béatrice, Gilson, Eric, Stoppacciaro, Antonella, Zupi, Gabriella, Biroccio, Annamaria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000812/
https://ncbi.nlm.nih.gov/pubmed/17932567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32461
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