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Progression from mitotic catastrophe to germ cell death in C. elegans lis-1 mutants requires the spindle checkpoint
Deletion of the lissencephaly disease gene LIS-1 in humans causes an extreme disorganization of the brain associated with significant reduction in cortical neurons. Here we show that deletion or RNA interference (RNAi) of Caenorhabditis elegans lis-1 results in a reduction in germline nuclei and cau...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000799/ https://ncbi.nlm.nih.gov/pubmed/17376425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.02.024 |
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