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Progression from mitotic catastrophe to germ cell death in C. elegans lis-1 mutants requires the spindle checkpoint

Deletion of the lissencephaly disease gene LIS-1 in humans causes an extreme disorganization of the brain associated with significant reduction in cortical neurons. Here we show that deletion or RNA interference (RNAi) of Caenorhabditis elegans lis-1 results in a reduction in germline nuclei and cau...

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Detalhes bibliográficos
Main Authors: Buttner, Edgar (Ned) A., Gil-Krzewska, Aleksandra J., Rajpurohit, Anandita K., Hunter, Craig P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000799/
https://ncbi.nlm.nih.gov/pubmed/17376425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.02.024
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