Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Gliclazide has been considered metabolized by CYP2C9. Its modified release formulation, gliclazide MR, shows low pharmacokinetic variability in Whites but high variability in Chinese. WHAT THIS STUDY ADDS: The results of this study show that the pharmacokine...

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Bibliographic Details
Main Authors:	Zhang, Yifan, Si, Dayong, Chen, Xiaoyan, Lin, Nan, Guo, Yingjie, Zhou, Hui, Zhong, Dafang
Format:	Artigo
Language:	Inglês
Published:	Blackwell Science Inc 2007
Subjects:	Pharmacogenetics
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2000619/ https://ncbi.nlm.nih.gov/pubmed/17298483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02846.x
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Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects

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