CYP2C19*2 Polymorphism Is Associated with Impaired Oral Clearance of Gliclazide in Healthy Chinese

BACKGROUND: Previous studies suggest gliclazide is metabolised primarily by CYP2C19 rather than CYP2C9, unlike other sulphonylureas. CYP2C19 *2 and *3 polymorphisms are more common in Asians. METHODS: We investigated the effect of CYP2C19 polymorphisms on gliclazide pharmacokinetics in 15 healthy ma...

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Vydáno v:Pharmgenomics Pers Med
Hlavní autoři: Chow, Elaine, Poon, Emily WM, Fok, Benny SP, Chan, Juliana CN, Tomlinson, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997415/
https://ncbi.nlm.nih.gov/pubmed/32099442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S226200
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