Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects

BACKGROUND: Bupropion (BUP) is an antidepressant and its pharmacological activity is mediated by its major metabolite, hydroxybupropion (HBUP). We investigated the effects of genetic polymorphisms of CYP2B6 on BUP and HBUP to provide certain evidence on the clinical rational administration of BUP. M...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Med Sci Monit
मुख्य लेखकों: Ma, Hui, Zhang, Wenping, Yang, Xiaoying, Zhang, Yuxin, Wei, Shijie, Zhang, Hao, Ma, Yanni, Dang, Hongwan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: International Scientific Literature, Inc. 2018
विषय:
Clinical Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914277/
https://ncbi.nlm.nih.gov/pubmed/29637923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.909227
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