Population pharmacokinetic and pharmacodynamic models of remifentanil in healthy volunteers using artificial neural network analysis

AIMS: An ordinary sigmoid E(max) model could not predict overshoot of electroencephalographic approximate entropy (ApEn) during recovery from remifentanil effect in our previous study. The aim of this study was to evaluate the ability of an artificial neural network (ANN) to predict ApEn overshoot a...

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Main Authors: Kang, S H, Poynton, M R, Kim, K M, Lee, H, Kim, D H, Lee, S H, Bae, K S, Linares, O, Kern, S E, Noh, G J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2007
Fag:
Pharmacokinetics & Pharmacodynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000605/
https://ncbi.nlm.nih.gov/pubmed/17324247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02845.x
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