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FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress

Circadian rhythms can be regulated by many environmental and endogenous factors. We show here a sensitivity of circadian clock function to oxidative stress that is revealed in flies lacking the foxo gene product. When exposed to oxidative stress, wild-type flies showed attenuated clock gene cycling...

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Detalhes bibliográficos
Main Authors: Zheng, Xiangzhong, Yang, Zhaohai, Yue, Zhifeng, Alvarez, John D., Sehgal, Amita
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000406/
https://ncbi.nlm.nih.gov/pubmed/17895391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701599104
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