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Stereoselective glucuronidation of carvedilol by Chinese liver microsomes

Objective: To study the stereoselective glucuronidation of carvedilol (CARV) by three Chinese liver microsomes. Methods: The metabolites of CARV were identified by a hydrolysis reaction with β-glucuronidase and HPLC-MS/MS. The enzyme kinetics for CARV enantiomers glucuronidation was determined by a...

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שמור ב:
מידע ביבליוגרפי
Main Authors: You, Lin-ya, Yu, Chun-na, Xie, Sheng-gu, Chen, Shu-qing, Zeng, Su
פורמט: Artigo
שפה:Inglês
יצא לאור: Zhejiang University Press 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1997231/
https://ncbi.nlm.nih.gov/pubmed/17910120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.2007.B0756
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