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Stereoselective glucuronidation of carvedilol by Chinese liver microsomes
Objective: To study the stereoselective glucuronidation of carvedilol (CARV) by three Chinese liver microsomes. Methods: The metabolites of CARV were identified by a hydrolysis reaction with β-glucuronidase and HPLC-MS/MS. The enzyme kinetics for CARV enantiomers glucuronidation was determined by a...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Zhejiang University Press
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1997231/ https://ncbi.nlm.nih.gov/pubmed/17910120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.2007.B0756 |
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