A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain
Human interleukin 4 (IL-4) binds to its cellular receptor with a K(d) in the subnanomolar range, similar to many other 4-helix-bundle proteins interacting with members of the hematopoietin (cytokine) receptor superfamily. In the IL-4 system this interaction is predominantly determined by the extrace...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19972/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050834/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.1657 |
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