A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain

Human interleukin 4 (IL-4) binds to its cellular receptor with a K(d) in the subnanomolar range, similar to many other 4-helix-bundle proteins interacting with members of the hematopoietin (cytokine) receptor superfamily. In the IL-4 system this interaction is predominantly determined by the extrace...

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Bibliographic Details
Main Authors: Wang, Yonghong, Shen, Bo-Jiang, Sebald, Walter
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19972/
https://ncbi.nlm.nih.gov/pubmed/9050834
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