A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain

Human interleukin 4 (IL-4) binds to its cellular receptor with a K(d) in the subnanomolar range, similar to many other 4-helix-bundle proteins interacting with members of the hematopoietin (cytokine) receptor superfamily. In the IL-4 system this interaction is predominantly determined by the extrace...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wang, Yonghong, Shen, Bo-Jiang, Sebald, Walter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19972/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050834/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.1657
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