B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4

To examine whether B7 costimulation can be mediated by a molecule on T cells that is neither CD28 nor CTLA4, we generated mice lacking both of these receptors. CD28/CTLA4(–/–) mice resemble CD28(–/–) mice in having decreased expression of T-cell activation markers in vivo and decreased T-cell prolif...

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Main Authors: Mandelbrot, Didier A., Oosterwegel, Mariette A., Shimizu, Koichi, Yamada, Akira, Freeman, Gordon J., Mitchell, Richard N., Sayegh, Mohammed H., Sharpe, Arlene H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC199576/
https://ncbi.nlm.nih.gov/pubmed/11285307
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