B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4
To examine whether B7 costimulation can be mediated by a molecule on T cells that is neither CD28 nor CTLA4, we generated mice lacking both of these receptors. CD28/CTLA4(–/–) mice resemble CD28(–/–) mice in having decreased expression of T-cell activation markers in vivo and decreased T-cell prolif...
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| Published in: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11285307/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11710 |
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